Issue 26, 2013

A potent antioxidant small molecule aimed at targeting metal-based oxidative stress in neurodegenerative disorders

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Abstract

Metal-ion misregulation and oxidative stress have been linked to the progressive neurological decline associated with multiple neurodegenerative disorders. Transition metal-mediated oxidation of biomolecules via Fenton chemical reactions plays a role in disease progression. Herein we report the synthesis, characterization and antioxidant activity of 2; a pyclen derivative with enhanced antioxidant character.

Supplementary files

Article information

Article type
Communication
Submitted
31 Aug 2012
Accepted
17 Dec 2012
First published
25 Feb 2013

Chem. Commun., 2013,49, 2712-2714

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A potent antioxidant small molecule aimed at targeting metal-based oxidative stress in neurodegenerative disorders

K. M. Lincoln, P. Gonzalez, T. E. Richardson, D. A. Julovich, R. Saunders, J. W. Simpkins and K. N. Green, Chem. Commun., 2013, 49, 2712 DOI: 10.1039/C2CC36808K

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