Oxidative Medicine and Cellular Longevity

The Role of Natural and Synthetic Antioxidants in Modulating Oxidative Stress in Drug-induced Injury and Metabolic Disorders 2020

Publishing date
01 Jun 2021
Submission deadline
29 Jan 2021

Lead Editor

1Beni-Suef University, Beni Suef, Egypt

2Manchester Metropolitan University, Manchester, UK

3Fairmont State University, Fairmont, USA

4PMAS-Arid Agriculture University, Rawalpindi, Pakistan

The Role of Natural and Synthetic Antioxidants in Modulating Oxidative Stress in Drug-induced Injury and Metabolic Disorders 2020


Oxidative stress is an imbalance in cellular redox reactions that plays a key role in the pathogenesis of metabolic disorders and drug-induced injury. Oxidative stress is the result of reactive oxygen species (ROS) overproduction or a decline in antioxidant defense mechanisms. Although ROS production can be beneficial in some instances as they are used by the immune system, in general, excessive generation of ROS results in deleterious effects causing damage to DNA, proteins, and lipids, ultimately leading to cell death. Several diseases, including cancer, neurodegeneration, obesity, metabolic syndrome, diabetes mellitus, liver disease, and others are well-known to be associated with excessive ROS production. Therefore, agents counteracting excess ROS and/or boosting the antioxidant defenses represent an appealing strategy for the treatment of multiple diseases.

Antioxidant substances could be natural or synthetic. Natural antioxidants are obtained entirely from natural sources and have been used in food, cosmetics, and pharmaceutical industries for some time. On the other hand, synthetic antioxidants are substances created from chemical processes. The current understanding of the complex role of ROS in physiological and pathological processes points to the necessity of developing multi-functional antioxidants, which can maintain oxidative homeostasis, both in health and in disease. In this context, numerous research groups focus on the characterization and application of natural antioxidant agents in different diseases. In addition, a great deal of effort is being conducted to design and synthesize free radical scavenging and antioxidant substances that can diminish excessive ROS production and improve the endogenous antioxidant defenses. Understanding and validating the biological activities of natural and synthetic antioxidant compounds and their molecular mechanisms in counteracting ROS and oxidative stress will provide a solid scientific foundation to the application of antioxidants in the prevention and treatment of multiple diseases.

We invite investigators to contribute original research, as well as review articles that illustrate the usefulness of natural and synthetic antioxidants as novel therapeutic approaches to prevent and fight metabolic diseases and drug-induced disorders. The purpose of the special issue will be to focus on articles describing the mechanism underlying the modulatory effect of natural and synthetic antioxidants on oxidative stress.

Potential topics include but are not limited to the following:

  • Role of ROS in metabolic and drug-induced disorders
  • In vitro and in vivo studies on the role of antioxidants in controlling redox imbalance
  • Modulators of redox-sensitive transcription factors
  • Characterization of the mechanism of action of natural and synthetic antioxidants
  • Natural and synthetic antioxidants as modulators of cellular signaling and metabolism
  • Novel approaches to identify the bioactivity of natural and synthetic antioxidants
  • Therapeutic application of antioxidants in oxidative stress-related diseases


Special Issue- Volume 2021- Article ID 9892021- EditorialThe Role of Natural and Synthetic Antioxidants in Modulating Oxidative Stress in Drug-Induced Injury and Metabolic Disorders 2020Ayman M. Mahmoud | Fiona L. Wilkinson | ... | Mansur A. Sandhu
Special Issue- Volume 2021- Article ID 5538470- Research ArticleRed Ginseng Oil Attenuates Oxidative Stress and Offers Protection against Ultraviolet-Induced Photo ToxicityH. M. Arif Ullah | Yuan Yee Lee | ... | Man Hee Rhee
Special Issue- Volume 2021- Article ID 6618874- Research ArticleMaternal Probiotic or Synbiotic Supplementation Modulates Jejunal and Colonic Antioxidant Capacity, Mitochondrial Function, and Microbial Abundance in Bama Mini-pigletsKai Wang | Xiangfeng Kong | ... | Qinghua He
Special Issue- Volume 2021- Article ID 5510230- Research ArticleComparative Studies on the Hepatoprotective Effect of White and Coloured Rice Bran Oil against Acetaminophen-Induced Oxidative Stress in Mice through Antioxidant- and Xenobiotic-Metabolizing SystemsWarunyoo Phannasorn | Arpamas Chariyakornkul | ... | Rawiwan Wongpoomchai
Special Issue- Volume 2021- Article ID 2732435- Research ArticlePharmacological Activation of Nrf2 by Rosolic Acid Attenuates Endoplasmic Reticulum Stress in Endothelial CellsKaran Naresh Amin | Palanisamy Rajagru | ... | Ramkumar Kunka Mohanram
Special Issue- Volume 2021- Article ID 5573357- Research ArticleMelatonin Alleviates the Toxicity of High Nicotinamide Concentrations in Oocytes: Potential Interaction with Nicotinamide Methylation SignalingMarwa El-Sheikh | Ahmed Atef Mesalam | ... | Il-Keun Kong
Special Issue- Volume 2021- Article ID 5521503- Research ArticleBu Shen Yi Sui Capsule Alleviates Neuroinflammation and Demyelination by Promoting Microglia toward M2 Polarization, Which Correlates with Changes in miR-124 and miR-155 in Experimental Autoimmune EncephalomyelitisZheng Zha | Yan-Fang Gao | ... | Lei Wang
Special Issue- Volume 2021- Article ID 6653593- Research ArticleInhibition of Calcium Oxalate Formation and Antioxidant Activity of Carboxymethylated Poria cocos PolysaccharidesChuang-Ye Li | Li Liu | ... | Jian-Ming Ouyang
Special Issue- Volume 2021- Article ID 6683836- Research ArticlePreclinical Evaluation of Safety, Pharmacokinetics, Efficacy, and Mechanism of Radioprotective Agent HL-003Yahong Liu | Longfei Miao | ... | Hongqi Tian
Special Issue- Volume 2021- Article ID 6679708- Research ArticleAscorbic Acid: A New Player of Epigenetic Regulation in LPS-gingivalis Treated Human Periodontal Ligament Stem CellsGuya D. Marconi | Luigia Fonticoli | ... | Francesca Diomede
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Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
Journal Citation Indicator0.710
Impact Factor6.543

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.

Antioxidant 1076